Nothing here is more than a quick sketch yet but here are some words.
Pandemic fatalism: government policy to "control" the Chinavirus pandemic failed miserably. What can be done? I'd argue that what should be done is more along the lines of: Nothing universalist. Lockdown the vulnerable and those who interact with them. Permit those of us who are at low risk and do not fear a disease to continue to live as we did. Policy should be drafted to ensure this. The best outcomes derive from permitting the virus to become endemic and permitting the population to naturally generate antibodies. Vaccine antibody production is universally inferior to naturally synthesized antibodies. Those who accept the risk should be permitted to live in a world where they have the opportunity to encounter pathogens and develop immunity. Healthy function in society is dependent on this kind of thing.
The Christian tradition must include explicit support for Sabbath-keeping, in addition to keeping the Lord's Day, Sunday. Forcing one of the two positions to submit is a potential characteristic of Antichrist religion. Until Christ's return and God's Kingdom is established, I would argue that the Christian church should support the believer's capacity to choose between them. The way to differentiate the Antichrist from the actual return of Christ is that the Antichrist will come in his own name whereas Jesus will come in the name of his Father, and the fake-Jew Talmudists will follow the Antichrist and not Jesus. - Colossians 2:16
RSS is like Twitter for the Web. Filters out low-effort posters, permits arbitrary re-aggregation.
Leaning into belief is how you can evaluate it. Incorrect belief will fail. "Magic" Twitter identity and sorcery parallel. I evaluated "magic" and discovered some of its weaknesses.
Gene therapy (also called human gene transfer) is a medical field which focuses on the utilization of the therapeutic delivery of nucleic acids into a patient's cells as a drug to treat disease.“Vaccine-Induced Covid-19 Mimicry” Syndrome is a literature review suggesting a solution to a particular problem of the AstraZeneca vaccine's function. It has a very good explanation of the function of the mRNA vaccines by Pfizer and Moderna along with that of AstraZeneca, and frames their difference well.
What is the fundamental difference between mRNA and vector-based vaccines? The mRNA vaccines are delivered by a lipid nanoparticle containing the appropriate mRNA molecule - coding for the spike protein of SARS-CoV-2 - to muscle cells surrounding the injection site. Cells that have successfully taken up these nanoparticles will release their cargo mRNA into the cytosol, where it will be translated into Spike protein in the rough endoplasmatic reticulum (ER). Subsequently, the translated and folded Spike proteins will be post-translationally modied in the ER and Golgi apparatus and transported to the outer membrane - as membrane-anchored proteins. This way, the immune system is able to recognize the viral antigen, which in turn triggers the initial events for all subsequent immunological processes to produce specific B- and T effector cells.https://sci-hub.ee/10.1126/science.8493530 https://www.webmd.com/lung/news/20210719/covid-19-vaccines-not-gene-therapy -- wrong https://journals.physiology.org/doi/abs/10.1152/ajplung.00223.2021 -- demonstrates cell damage https://www.forbes.com/sites/brucelee/2021/03/17/covid-19-mrna-vaccines-are-not-gene-therapy-as-some-are-claiming/ - Forbes can't even keep it straight. - The U.S. National Library of Medicine (NLM) describes gene therapy as a technique that “may allow doctors to treat a disorder by inserting a gene into a patient’s cells instead of using drugs or surgery.” - https://pubmed.ncbi.nlm.nih.gov/33772572/ - Development of COVID-19 vaccines utilizing gene therapy technology https://investors.modernatx.com/static-files/a6de7d15-3e57-404a-88c7-78b32f244125 - PDF "Currently, mRNA is considered a gene therapy product by the FDA" https://asgct.org/research/news/november-2020/covid-19-moderna-nih-vaccine -- "These findings, announced by Moderna on Nov. 16 and by Pfizer and its partner BioNTech on Nov. 9 (with an update on Nov. 18), demonstrate that gene therapy is a viable strategy for developing vaccines to combat COVID-19." -- NewSpeak at work, similar dynamics with "vaccine". https://www.fda.gov/vaccines-blood-biologics/cellular-gene-therapy-products/what-gene-therapy -- FDA gene therapy definition https://archive.ph/UHfw4 https://www.canada.ca/en/health-canada/services/science-research/emerging-technology/biotechnology/about-biotechnology/gene-therapy.html - canada - Gene therapy is using "genes as medicine". It is an experimental approach to treating genetic disease where the faulty gene is fixed, replaced or supplemented with a healthy gene so that it can function normally. - To get a new gene into a cell's genome, it must be carried in a molecule called a vector. The most common vectors currently being used are viruses, which naturally invade cells and insert their genetic material into that cell's genome. - https://archive.ph/oBpaq https://www.merckmanuals.com/en-ca/professional/special-subjects/general-principles-of-medical-genetics/clinical-uses-of-genetics - Gene therapy can broadly be considered any treatment that changes gene function. However, gene therapy is often considered specifically the insertion of normal genes into the cells of a person who lacks such normal genes because of a specific genetic disorder. The normal genes can be manufactured, using polymerase chain reaction (PCR) methodology, from normal DNA donated by another person. Because most genetic disorders are recessive, usually a dominant normal gene is inserted. Currently, such insertion gene therapy is most likely to be effective in the prevention or cure of single-gene defects , such as cystic fibrosis. - https://archive.ph/hIdus - MERCK MANUAL Professional Version https://advances.sciencemag.org/content/7/24/eabf1771 - Polθ reverse transcribes RNA and promotes RNA-templated DNA repair https://en.wikipedia.org/wiki/POLQ https://phys.org/news/2021-06-discovery-human-cells-rna-sequences.html https://scitechdaily.com/new-discovery-shows-human-cells-can-write-rna-sequences-into-dna-challenges-central-principle-in-biology/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741561/ - discusses early tragedy in gene therapy - Gene therapy represents an innovating and appealing strategy for treatment of human diseases, which utilizes vehicles or vectors for delivering therapeutic genes into the patients' body. - However, a few past unsuccessful events that negatively marked the beginning of gene therapy resulted in the need for further studies regarding the design and biology of gene therapy vectors, so that this innovating treatment approach can successfully move from bench to bedside. - Adenoviruses are a family of DNA viruses, which are comprised of a double stranded DNA genome of 36 kilobases (Kb) encapsulated within the viral capsid. https://www.nature.com/articles/3301923 - talks about moderna design - The success of gene therapy is largely dependent on the development of the gene delivery vector. https://www.nature.com/articles/nrd.2017.243 - mRNA vaccines — a new era in vaccinology nature article re mrna https://www.nature.com/articles/s41467-020-19505-2 - once and future gene therapy https://www.novartis.com/our-focus/cell-and-gene-therapy/what-cell-and-gene-therapy - Gene therapy aims to treat diseases by replacing, inactivating or introducing genes into cells— either inside the body (in vivo) or outside of the body (ex vivo)6. - Cites ASGCT "Vaccination" definition changes per CDC https://web.archive.org/web/20140709164130/http://www.cdc.gov/vaccines/vac-gen/imz-basics.htm - Vaccination: Injection of a killed or weakened infectious organism in order to prevent the disease. https://web.archive.org/web/20141010112625/http://www.cdc.gov/vaccines/vac-gen/imz-basics.htm - ... https://archive.ph/AJicU - https://www.britannica.com/science/vaccine - Vaccine, suspension of weakened, killed, or fragmented microorganisms or toxins or of antibodies or lymphocytes that is administered primarily to prevent disease. https://www.lawinsider.com/dictionary/vaccine - legal definitions of vaccine https://www.lawinsider.com/dictionary/gene-therapy - ...
What happens to the same Spike gene when delivered via an adenoviral system? The adenovirus life cycle includes the infection of cells, uncoating of the virus in the cytosol, entry of the adenoviral DNA into the nucleus, and subsequently gene transcription by the host transcription machinery (6). All adenoviral systems follow exactly these steps (Ad5, Ad26 and chimp Ad). Thus, the SARS-CoV-2 Spike gene will be transcribed inside of the nucleus and subsequently exported as mRNA out of the nucleus. Arriving in the cytosol, the mRNA will again be translated into the Spike protein (see above)